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BMS235 Protein Biochemistry

This subject gives an overview of protein structure and function. Experimental methods of analysis and manipulation of proteins are covered in both theory and laboratory exercises. Special reference is given to the application of proteins in biotechnology.

Subject Information

Grading System

HD/FL

Duration

One session

School

School of Biomedical Sciences

Assumed Knowledge

This subject has no prerequisites although successful completion of BCM210 or equivalent is assumed.

Learning Outcomes

Upon successful completion of this subject, students should:

• be able to describe in detail the structure of proteins
• be able to describe the forces involved in protein folding
• be able to describe the role of proteins in ligand binding, such as in enzyme action
• be able to describe the analytical principles behind the common methods of protein separation, purification, analysis and structural determination
• be able to perform common experimental methods used to manipulate proteins, such as electrophoresis, centrifugation and immunochemical methods
• be able to describe functional assays used to study proteins
• be able to describe the applications of protein engineering

Syllabus

This subject will cover the following topics:

• basic aspects of polypeptide structure
• the three dimensional structure of proteins, including:
  • secondary structure, alpha helix, beta sheets, and beta turns
  • tertiary structure, including protein motifs and domains
  • quaternary structure
• ligand binding and function
• methods of determination of protein structure
• protein expression and purification techniques
• protein detection and analysis techniques
• protein engineering

Residential School

This subject contains a 3 day Compulsory Residential School. Upon successful completion of the residential school, students will be able to perform common techniques used to manipulate proteins such as electrophoresis, centrifugation and immunochemical methods.

Availability

• Offering has a residential school
• Session 2 (60)
  • On Campus: Wagga Wagga Campus
  • Online: Wagga Wagga Campus