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Course Overview

The course CB2300, Analysis and modelling of biomolecular therapeutics, is a 7.5 credit course that provides an in-depth understanding of how the precise structure and dynamic behavior of biomolecular drugs affect their function.

Content and Learning Outcomes

Course Contents

The course covers theoretical and practical skills in generating and analyzing datasets with a focus on small-angle scattering (SAS) and cryo-electron microscopy (cryo-EM). It also covers computational modeling for atomistic refinement and detailed characterization of biomolecular structures and their ensembles. The course discusses how these methods, combined with ongoing innovation in machine learning, are accelerating modern drug development.

Intended Learning Outcomes

After completing the course, the student should be able to:

• Explain the basic principles of structural analysis methods and critically evaluate their strengths and limitations in the development of biomolecular drugs.
• Use relevant computational tools and software to process, analyze, and interpret extensive experimental datasets from structural analysis of biomolecular drugs.
• Assess the quality of data fitting to assess the reliability and certainty of models in both experimental and theoretical data.
• Utilize results from structural analysis and modeling to create insights into mechanisms of action and design principles for biomolecular drugs and justify and communicate the methodological choices that form the basis for the conclusions.

Literature and Preparations

Specific Prerequisites

Completed bachelor's degree project 15 credits, 20 credits in cell biology, biochemistry, microbiology, and genetic engineering/molecular biology, 15 credits in mathematics, numerical analysis, and computer technology, and courses in programming equivalent to at least 5 credits.

Literature

Information about course literature can be found in the course memo for the course offering or in the course room in Canvas.

Examination and Completion

Grading Scale

A, B, C, D, E, FX, F

Examination

• TEN1 - Written exam, 3.5 credits, grading scale: A, B, C, D, E, FX, F
• PRO1 - Project work, 2.5 credits, grading scale: P, F
• LAB1 - Laboratory Work, 1.5 credits, grading scale: P, F

Based on recommendation from KTH's coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability. The examiner may apply another examination format when re-examining individual students. If the course is discontinued, students may request to be examined during the following two academic years.

Further Information

Offered by

CBH/Protein Science

Main field of study

Biotechnology

Education cycle

Second cycle