Folate-Degrader Conjugates (FDCs) for Tumour-specific Targeting
Program Overview
PhD Program in Cancer Research
The Institute of Cancer Research offers a PhD program in cancer research, providing students with the opportunity to work on cutting-edge projects and contribute to the advancement of cancer treatment.
Program Overview
The PhD program is designed to equip students with the knowledge, skills, and expertise necessary to pursue a career in cancer research. The program is structured to provide students with a comprehensive understanding of cancer biology, as well as the technical skills required to design and conduct research projects.
Research Areas
The Institute of Cancer Research has a strong focus on the following research areas:
- Breast Cancer Research
- Cancer Biology
- Cancer Therapeutics
- Cell and Molecular Biology
- Clinical Studies
- Genetics and Epidemiology
- Radiotherapy and Imaging
- Structural Biology
PhD Projects
The Institute offers a range of PhD projects, including:
- Folate-Degrader Conjugates (FDCs) for Tumour-specific Targeting
- Development of GSPT-targeting folate conjugates
- Evaluation of FDCs in a range of FOLR positive and negative cell lines
Project Aims
The ultimate objective of the PhD project is to demonstrate that Folate Degrader Conjugates (FDCs) retain potency while displaying greater in vitro therapeutic window in respect to normal noncancerous cells when compared to the corresponding Molecular Glue Degraders (MGDs).
Candidate Profile
Applicants should have an Undergraduate Honours degree (First or 2:1) in organic chemistry.
Literature References
The PhD project is based on the following literature references:
- Békés, M.; Langley, D. R.; Crews, C. M. PROTAC Targeted Protein Degraders: The Past Is Prologue. Nat Rev Drug Discov 2022.
- Geiger, T. M.; Schäfer, S. C.; Dreizler, J. K.; Walz, M.; Hausch, F. Clues to Molecular Glues. Current Research in Chemical Biology 2022, 2.
Program Requirements
The PhD program requires students to:
- Complete a research project under the supervision of a principal investigator
- Attend seminars and workshops
- Participate in journal clubs and research meetings
- Present research findings at national and international conferences
Tuition Fees
Tuition fees are not specified, but students are encouraged to contact the Institute for more information.
Student Life and Support
The Institute provides a range of support services for students, including:
- Accommodation support
- Welfare services
- Social events
- Academic and career support
- Student resources
- Student stories
- Alumni stories
Careers at the ICR
The Institute offers a range of career opportunities, including:
- Postdocs
- Research scientists and scientific support
- Group leaders
- Clinicians
- Professional Service roles
- Apprenticeships
Working Life and Benefits
The Institute provides a range of benefits, including:
- Staff benefits
- World-leading working facilities
- Equality and social groups
- Career development
- Employee stories
Industry Partnerships
The Institute has partnerships with a range of industry partners, including:
- AstraZeneca
- Orum Therapeutics
About Us
The Institute of Cancer Research is a charity dedicated to cancer research. Our mission is to make a positive impact on cancer treatment and patient care.
Contact Information
Not available due to the constraints of the task.