Synthesis of Lamellarin alkaloids using photoredox catalysis
| Program start date | Application deadline |
| 2024-01-01 | - |
| 2024-04-01 | - |
| 2024-07-01 | - |
| 2024-10-01 | - |
Program Overview
This PhD program focuses on the synthesis of lamellarin alkaloids using photoredox catalysis. The program offers opportunities for careers in pharmaceutical research, medicinal chemistry, and natural product research.
Program Outline
Careers:
The program can potentially lead to careers in various fields related to the synthesis and development of pharmaceuticals and biologically active natural products. Graduates may find opportunities in areas like:
- Pharmaceutical research and development: Developing and researching new drugs and treatments for various diseases.
- Medicinal chemistry: Designing and synthesizing new drug candidates.
- Natural product research: Studying the chemical composition of plants and other natural sources to discover new bioactive molecules.
- Academic research: Conducting research and teaching in universities or other research institutions.
Other:
- The research group focuses on the synthesis of heterocycles, particularly using singlet oxygen and activation of enamides and allenamides. This chemistry can be used for the rapid construction of biologically active natural products, and heterocycles of pharmaceutically relevance.
- More than 70 lamellarins and related pyrrole-derived alkaloids have been isolated and identified.
- These compounds exhibit fascinating and significant biological properties. This includes cytotoxicity and antitumor activity, multidrug resistance (MDR), HIV-1 integrase inhibition, antibiotic activity, cell division inhibition, immuno-modulatory activity, antioxidant activity, and feeding deterrence.
- Traditional syntheses of this natural product class have centered on palladium coupling of pyrrole bromides with aryl boronic acids with subsequent alkylation of the pyrrole nitrogen or Diels-Alder reaction of a disubstituted alkynes with subsequent functional group manipulation.
- This program will utilize a recently reported photoredox mediated addition of radicals to enamides, followed by subsequent nucleophile trapping.
- This project will develop an intramolecular variant of this unique process that ultimately will deliver a total synthesis of the core heterocyclic structure of the lamellarins.
UK fee £4,712 Full-time degree per annum International fee £26,000 Full-time degree per annum University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Fees are reviewed annually and are likely to increase to take into account inflationary pressures.
Loughborough University
Overview:
Loughborough University is a public research university located in Loughborough, Leicestershire, England. It is renowned for its strong academic programs, particularly in sports science, engineering, and business. The university boasts a vibrant campus life and a strong focus on research and innovation.
Student Life and Campus Experience:
Loughborough University offers a diverse and engaging campus experience. Students can participate in a wide range of extracurricular activities, including sports, societies, and volunteering opportunities. The university has a strong sporting heritage and is home to world-class facilities. Students can also enjoy a vibrant social scene with numerous bars, restaurants, and events happening on campus.
Key Reasons to Study There:
World-class facilities:
Loughborough University boasts state-of-the-art facilities, including a dedicated sports village, a modern library, and cutting-edge research labs.Strong academic reputation:
The university is consistently ranked among the top universities in the UK for its academic excellence.Vibrant campus life:
Students can enjoy a lively and diverse campus community with numerous opportunities for social interaction and personal development.Focus on research and innovation:
Loughborough University is a leading research institution, with a strong focus on tackling real-world challenges.Excellent career prospects:
Graduates from Loughborough University are highly sought after by employers, with strong career prospects in various fields.Academic Programs:
Loughborough University offers a wide range of undergraduate and postgraduate programs across various disciplines, including:
Engineering:
Aerospace, Chemical, Civil, Electrical, Mechanical, and more.Business and Economics:
Accounting, Finance, Management, Marketing, and more.Sport Science:
Exercise Science, Sports Coaching, Sports Management, and more.Humanities and Social Sciences:
Psychology, Sociology, History, and more.Science and Technology:
Chemistry, Physics, Computer Science, and more.Other:
Loughborough University has a strong commitment to sustainability and social responsibility. The university is actively working towards achieving net-zero carbon emissions and promoting inclusivity and diversity within its community.
Entry Requirements:
United Kingdom
- Applicants should have or expect to achieve at least a 2:1 honours degree (or equivalent international qualification) in chemistry.
Afghanistan
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Diploma of Nivel Superior (First Level (University) Diploma (from 2010)
- 9.5
- 8.5
- 8
Albania
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Diploma e Nivelit të Pare (First Level (University) Diploma (from 2010)
- 9.5
- 8.5
- 8
Algeria
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Licence (4 year) / Diplome d'Inginieur d'Etat / Diplôme d'Etudes Supérieures
- 16
- 14
- 12
Argentina
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Licenciatura/ Licenciado (4 year)
- 8.5
- 7.5
- 6.0
Armenia
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Bakalavri Kochum required but typically a Magistrosi Kochum
- 90% or 3.9
- 80% or 3.5
- 70% or 3.0
Australia
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Honours degree (AQF level 8)
- First Class, 80%
- Upper Second, 70%, H2A
- Lower Second, 60%, 2B
- Ordinary degree - AQF Level 7 pass (mark 46 or 50)
- High Distinction (80% or 85%)
- Distinction (75% or 80%)
- Distinction (70% or 75%)
Austria
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Degree/ Diplomstudium / Magister degree
- A (or 1.5) mit Auszeichnungbestanden 60% or B (or 3.0)
- 50% or C (or 2.7)
Azerbaijan
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Bakalavr Diplomu/ Diplomu (Specialist Diploma)
- 4.5 or 90%
- 4 or 80%
- 3.5 or 70%
Bahamas
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Degree from University of the West Indies only
- 1st (GPA 3.6)
- 2:1 (GPA 3.0)
- 2:2 (GPA 2.5)
Bahrain
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- GPA 4.0 scale
- 3.5
- 3.0
- 2.8
Bangladesh
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- 4 year Bachelor of Science in Engineering (IEB and BAETE accredited courses only)
- 1st (70%) / 3.5
- 2nd (60%) / 3.0
- 2nd (55%) / 2.75
- Masters (1-2 years) following a 3 or 4 year degree
- 80% / 4.0
- 65% / 3.25
- 50% / 2.5
Barbados
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- University of the West Indies, Honours degree
- 1st (GPA 3.6)
- 2:1 (GPA 3.0)
- 2:2 (GPA 2.5)
- Barbados Community College
- 1st or GPA 3.75
- 2:1 or GPA 3.5
- 2:2 or GPA 3.0
Belarus
- First-class honours (70%)
- Upper second-class honours (60%)
- Lower second-class honours (50%)
- Specialist Diploma (5Yr)
- 9
- 7
- 5
Belgium
- First-class honours (70%)
- Upper second-class honours (60%)
