Development of novel bicyclopentanes (BCP) bioisosteres from bench stable [1.1.1]-propellane precursors
| Program start date | Application deadline |
| 2024-07-01 | - |
| 2024-10-01 | - |
| 2025-01-01 | - |
Program Overview
BCPs are promising bioisosteres with applications in medicinal chemistry, drug development, and the agrochemical sector. The program offers an excellent training platform in a state-of-the-art laboratory, significantly expanding the synthetic scope of BCPs.
Program Outline
Teaching:
- This program is part of a new state-of-the-art laboratory at Loughborough University.
- The program provides an excellent training platform for the prospective PhD candidate.
Other:
- Bicyclo-[1.1.1]-pentanes (BCPs) are an exciting class of strained, sp3 rich carbon.
- Their initial use was in the materials sector, but recent impact has been in medicinal chemistry, drug development and the agrochemical sector.
- Their synthesis is accomplished using hetero- or homolytic cleavage and relies on the inherent strain in the central carbon-carbon bond of [1.1.1]-propellane.
- However, the practical isolation and storage of [1.1.1]-propellane is very problematic; it is isolated as a solution in ethereal solvents, it must be cryogenically stored, and should be used before its rapid degradation.
- The project will pioneer a stable crystalline alternatives of [1.1.1]-propellane.
UK fee £4,712 Full-time degree per annum International fee £26,000 Full-time degree per annum 2024-25 tuition fees are applicable to projects starting in October 2024, January 2025, April 2025 and July 2025. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Fees are reviewed annually and are likely to increase to take into account inflationary pressures.
Loughborough University
Overview:
Loughborough University is a public research university located in Loughborough, Leicestershire, England. It is renowned for its strong academic programs, particularly in sports science, engineering, and business. The university boasts a vibrant campus life and a strong focus on research and innovation.
Student Life and Campus Experience:
Loughborough University offers a diverse and engaging campus experience. Students can participate in a wide range of extracurricular activities, including sports, societies, and volunteering opportunities. The university has a strong sporting heritage and is home to world-class facilities. Students can also enjoy a vibrant social scene with numerous bars, restaurants, and events happening on campus.
Key Reasons to Study There:
World-class facilities:
Loughborough University boasts state-of-the-art facilities, including a dedicated sports village, a modern library, and cutting-edge research labs.Strong academic reputation:
The university is consistently ranked among the top universities in the UK for its academic excellence.Vibrant campus life:
Students can enjoy a lively and diverse campus community with numerous opportunities for social interaction and personal development.Focus on research and innovation:
Loughborough University is a leading research institution, with a strong focus on tackling real-world challenges.Excellent career prospects:
Graduates from Loughborough University are highly sought after by employers, with strong career prospects in various fields.Academic Programs:
Loughborough University offers a wide range of undergraduate and postgraduate programs across various disciplines, including:
Engineering:
Aerospace, Chemical, Civil, Electrical, Mechanical, and more.Business and Economics:
Accounting, Finance, Management, Marketing, and more.Sport Science:
Exercise Science, Sports Coaching, Sports Management, and more.Humanities and Social Sciences:
Psychology, Sociology, History, and more.Science and Technology:
Chemistry, Physics, Computer Science, and more.Other:
Loughborough University has a strong commitment to sustainability and social responsibility. The university is actively working towards achieving net-zero carbon emissions and promoting inclusivity and diversity within its community.
Entry Requirements:
Undergraduate Degrees:
- Applicants should have or expect to achieve at least a 2:1 honours degree (or equivalent) in chemistry.
- Applicants with a 2:2 honours degree may be considered on a case-by-case basis if they have relevant experience.
- International Baccalaureate (IB) Diploma: 34 points overall, including 17 points in higher level subjects including Chemistry.
- BTEC Extended Diploma: Distinction, Distinction, Merit in a science-related subject.
Master's Degrees:
- Applicants should have or expect to achieve at least a 2:1 honours degree (or equivalent) in chemistry or a related subject.
- Applicants with a 2:2 honours degree may be considered on a case-by-case basis if they have relevant experience.
- A minimum IELTS score of 6.5 (with no individual component below 6.0) or equivalent.
- A minimum TOEFL score of 90 (with a minimum of 20 in Reading, Listening, and Speaking, and 22 in Writing) or equivalent.
Research Degrees:
- Applicants should have or expect to achieve at least a 2:1 honours degree (or equivalent) in chemistry or a related subject.
- A strong academic record in chemistry, with a proven ability to conduct independent research.
- Excellent communication and interpersonal skills.
- A minimum IELTS score of 6.5 (with no individual component below 6.0) or equivalent.
- A minimum TOEFL score of 90 (with a minimum of 20 in Reading, Listening, and Speaking, and 22 in Writing) or equivalent.
Additional Requirements:
- A personal statement outlining your academic and research interests.
- Two academic references.
- A CV or resume.
- A research proposal (for research degrees only).
Language Proficiency Requirements:
- Applicants whose first language is not English must demonstrate proficiency in the English language.
- You must achieve a minimum IELTS score of 6.5 (with no individual component below 6.0) or equivalent.
- You must achieve a minimum TOEFL score of 90 (with a minimum of 20 in Reading, Listening, and Speaking, and 22 in Writing) or equivalent. Specific requirements may vary depending on the research area and the supervisor.
