Program Overview

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Human Genetics and Genomics, PhD

The Johns Hopkins Human Genetics and Genomics Training Program provides training in all aspects of human genetics and genomics relevant to human biology, health, and disease.

Overview

Advances in human genetics and genomics continue at an astounding rate and increasingly they are being integrated into medical practice. The Human Genetics and Genomics Program aims to educate highly motivated and capable students with the knowledge and experimental tools that will enable them to answer important questions at the interface between genetics and medicine.

Program Objectives

The overall objective of the Human Genetics program is to provide students with a strong foundation in basic science by exposure to a rigorous graduate education in genetics, genomics, molecular biology, cell biology, biochemistry, and biostatistics, as well as a core of medically-related courses selected to provide knowledge of human biology in health and disease.

Research Facilities

Research laboratories are well-equipped to carry out sophisticated research in all areas of genetics. The proximity to renowned clinical facilities of the Johns Hopkins Hospital, including the Department of Genetic Medicine, and Oncology Center provides faculty and students with access to a wealth of material for study. Computer and library facilities are excellent.

Financial Aid

The program is supported by a training grant from the National Institute of General Medical Sciences. These fellowships, which are restricted to United States citizens and permanent United States residents, cover tuition, health care insurance, and a stipend during year one. Once a student has joined a thesis lab, all financial responsibilities belong to the mentor.

Admission Requirements

Applicants for admission should show a strong academic foundation with coursework in biology, chemistry, and quantitative analysis. Applicants are encouraged to have exposure to lab research or to data science. A bachelor's degree from a qualified college or university will be required for matriculation.

Program Requirements

The program includes the following required core courses:

• Advanced Topics in Human Genetics
• Evolving Concepts of the Gene
• Molecular Biology and Genomics
• Cell Structure and Dynamics
• Computational Bootcamp
• Pathways and Regulation
• Genomic Technologies
• Rigor and Reproducibility in Research
• Systems, Genes, and Mechanisms of Disease

Numerous elective courses are available. Trainees must take a minimum of four electives, one of which must provide computational/statistical training.

Career Development

The program requires the "OPTIONS" Career Curriculum offered by the Professional Development and Career Office. OPTIONS is designed to provide trainees with the skills for career building and the opportunity for career exploration as well as professional development training.

Research Rotations and Thesis

Trainees must complete three research rotations before deciding on their thesis lab. They must also participate in the Responsible Conduct of Research sessions offered by the Biomedical Program.

Assessment and Evaluation

At the end of the second year, trainees take their Doctoral Board Oral Examination. Annual thesis committee meetings must be held following successful completion of this exam.

Course List

The following courses are part of the program:

• ME.710.700: Advanced Topics in Human Genetics
• ME.710.748: Introduction to Rigor and Reproducibility in Research
• ME.710.745: Evolving Concepts of the Gene
• ME.800.811: Introduction to Responsible Conduct of Research
• ME.710.746: Human Genetics Boot Camp
• ME.110.728: Cell Structure and Dynamics
• ME.260.709: Molecular Biology and Genomics
• ME.710.800: Independent Research
• ME.710.747: Systems, Genes, and Mechanisms in Disease
• ME.710.744: Genomic Technologies
• ME.710.740: Understanding Genetic Disease
• ME.360.728: Pathways and Regulation

Career Outcomes

Graduates from the Human Genetics program pursue careers in academia, medicine, industry, teaching, government, law, as well as the private sector. Our trainees are encouraged to explore the full spectrum of professional venues in which their training may provide a strong foundation.