Program Overview

Introduction to the Cornea & External Eye Diseases Fellowship Programme

The Cornea and External Eye (CEE) Diseases Service of the Department of Ophthalmology and Visual Sciences operates at both the Hong Kong Eye Hospital and the Prince of Wales Hospital, the teaching hospitals of the Chinese University of Hong Kong. Our 4 CEE Subspecialty Clinics serve the populations living in Kowloon and the eastern region of the New Territories in Hong Kong, and are well attended by up to 300 patients each week.

Program Overview

• The CEE Fellows of the CUHK-HKEH-PWH International Ophthalmology Fellowship Programme will actively participate in all clinical services and various research projects.
• During the Fellowship, each Fellow should aim to be the Principal Investigator of at least 1 CEE research project at CUHK.
• At the conclusion of the Fellowship, each Fellow should be confident in the diagnosis and treatment of common CEE diseases, and should have at least 1 publication as first author arising from research done during his / her CUHK Fellowship.

Clinical Expertise

1. Management of corneal and external eye diseases
2. Penetrating and lamellar keratoplasties
3. Eyebanking
4. Complex cataract surgery, IOL exchange and secondary IOL implantation
5. Management of a wide range of glaucoma (including primary open/closed angle glaucoma, normal tension glaucoma, uveitic glaucoma, pediatric glaucoma, neovascular glaucoma)
6. Various imaging of glaucoma patients
7. Complex cataract surgeries and filtration surgeries for glaucoma patients

Clinical Attachment for CEE

• Up to 4 CEE Clinics per week at Hong Kong Eye Hospital and Prince of Wales Hospital
• At least 1 CEE Operating List per week
• At least 1 CEE Imaging Session per month

Surgical Procedures at Hong Kong Eye Hospital and Prince of Wales Hospital

• Ocular Surface Reconstruction – limbal stem cell +/- amniotic membrane +/- other types of grafting
• Collagen Cross Linking
• Pupilloplasty
• Keratoprosthesis
• Keratoplasty (simple and combined)

  Penetrating
  Lamellar ( Deep anterior lamellar keratoplasty / Endothelial Keratoplasty )

Imaging Modalities at Hong Kong Eye Hospital and Prince of Wales Hospital

• Anterior Segment OCT
• Confocal Microscopy
• Ultrasound bio microscopy

Research Fields

The CUHK CEE Subspecialty has a track record in covering comprehensively all major key areas of anterior segment conditions. Our broad interest includes laboratory, clinical and surgical studies, ranging from corneal erosion, anterior segment imaging, ocular surface reconstruction to keratoplasty. The faculty are recognised internationally and delivered many lectures and courses both locally & overseas.

Recent Representative Publications

1. Chow SSW, Chan TCY, Wong IYH, Fan MCY, Lai JSM, Ng ALK. Early epithelial complications of accelerated trans-epithelial corneal crosslinking in treatment of keratoconus: a case series. Int Ophthalmol. 2018 Dec;38(6):.
2. Wang YM, Ma L, Lu SY, Chan TCY, Yam JCS, Tang SM, Kam KW, Tam POS, Tham CC, Young AL, Jhanji V, Pang CP, Chen LJ. Analysis of multiple genetic loci reveals MPDZ-NF1B rs as a putative genetic marker for keratoconus. Br J Ophthalmol. 2018 Dec;102(12):.
3. Yan MK, Chang JS, Chan TC. Refractive regression after laser in situ keratomileusis. Clin Exp Ophthalmol. 2018 Nov;46(8):934-944.
4. Chan TCY, Chan JCK, Wang YM, Rapuano CJ. Survival Analysis of Corneal Densitometry After Collagen Cross-Linking for Progressive Keratoconus. Cornea. 2018 Nov;37(11):.
5. Young AL, Cao D, Chu WK, Ng TK, Yip YWY, Jhanji V, Pang CP. The Evolving Story of Pterygium. Cornea. 2018 Nov;37 Suppl 1:S55-S57.
6. Ng ALK, Chan TCY, Cheng ACK. Comparison of Different Corneal Power Readings From Pentacam in Post-laser In Situ Keratomileusis Eyes. Eye Contact Lens. 2018 Nov;44 Suppl 2:S370-S375.
7. Qin YJ, Chu WK, Huang L, Ng CHY, Chan TCY, Cao D, Yang C, Zhang L, Huang SP, Li J, Lin HL, Li WQ, Chen L, Schally AV, Chan SO, Zhang HY, Pang CP. Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone-Releasing Hormone Receptors. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):.
8. Zhao Y, Tan S, Chan TCY, Xu Q, Zhao J, Teng D, Fu H, Wei S. Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. Br J Ophthalmol. 2018 Oct;102(10):.
9. Chan TCY, Wang YM, Yu M, Jhanji V. Comparison of Corneal Tomography and a New Combined Tomographic Biomechanical Index in Subclinical Keratoconus. J Refract Surg. 2018 Sep 1;34(9):616-621.
10. Wan KH, Chan TC, Yu M, Jhanji V. Longitudinal evaluation of posterior corneal changes after laser in situ keratomileusis in high myopia: a swept-source optical coherence tomography study. Clin Exp Ophthalmol. 2018 Sep;46(7):824-826.
11. Ng ALK, Cheng GPM, Woo VCP, Jhanji V, Chan TCY. Comparing a new hydroexpression technique with conventional forceps method for SMILE lenticule removal. Br J Ophthalmol. 2018 Aug;102(8):.
12. Wang YM, Chan TC, Yu MCY, Jhanji V. Comparative evaluation of progression rate in keratoconus before and after collagen crosslinking. Br J Ophthalmol. 2018 Aug;102(8):.
13. Ma J, Wang Y, Chan TCY. Possible Risk Factors and Clinical Outcomes of Black Areas in Small-Incision Lenticule Extraction. Cornea. 2018 Aug;37(8):.
14. Chan TC, Cheng GP, Jhanji V, Wang Y. Adjuvant collagen crosslinking for treatment of epithelial ingrowth after small-incision lenticule extraction. Clin Exp Ophthalmol. 2018 Jul;46(5):554-556.
15. Zhang Y, Wang Y, Li L, Dou R, Wu W, Wu D, Jhanji V. Corneal Stiffness and its Relationship With Other Corneal Biomechanical and Nonbiomechanical Parameters in Myopic Eyes of Chinese Patients. Cornea. 2018 Jul;37(7):881-885.
16. Chan TCY, Wong ES, Chan JCK, Wang Y, Yu M, Maeda N, Jhanji V. Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography. Acta Ophthalmol. 2018 May;96(3):e327-e333.
17. Chan TCY, Wan KH, Shih KC, Jhanji V. Advances in dry eye imaging: the present and beyond. Br J Ophthalmol. 2018 Mar;102(3):295-301.
18. Chan TC, Wang YM, Yu M, Jhanji V. Comparison of corneal dynamic parameters and tomographic measurements using Scheimpflug imaging in keratoconus. Br J Ophthalmol. 2018 Jan;102(1):42-47.
19. Kam KW, Yung W, Li GKH, Chen LJ, Young AL. Infectious keratitis and orthokeratology lens use: a systematic review. Infection. 2017 Dec;45(6):727-735.
20. Kam KW, Chen LJ, Wat N, Young AL. Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-677.
21. Mercer RN, Waring GO 4th, Roberts CJ, Jhanji V, Wang Y, Filho JS, Hemings RA Jr, Ro Comparison of Corneal Deformation Parameters in Keratoconic and Normal Eyes Using a Non-contact Tonometer With a Dynamic Ultra-High-Speed Scheimpflug Camera. cha KM. J Refract Surg. 2017 Sep 1;33(9):625-631.
22. Wang YM, Chan TCY, Yu M, Jhanji V. Comparison of Corneal Dynamic and Tomographic Analysis in Normal, Forme Fruste Keratoconic, and Keratoconic Eyes. J Refract Surg. 2017 Sep 1;33(9):632-638.
23. Faith SC, Jhanji V. Refractive Surgery: History in the Making. Asia Pac J Ophthalmol (Phila). 2017 Sep-Oct;6(5):401-402.
24. Chan TC, Biswas S, Yu M, Jhanji V. Comparison of corneal measurements in keratoconus using swept-source optical coherence tomography and combined Placido-Scheimpflug imaging. Acta Ophthalmol. 2017 Sep;95(6):e486-e494.
25. Yao Y, Zhang MZ, Jhanji V. Surgical management of limbal dermoids: 10-year review.
    Acta Ophthalmol. 2017 Sep;95(6):e517-e518.
26. Chan TCY, Ng ALK, Cheng GPM, Woo VCP, Zhang J, Wang Y, Jhanji V.
    Effect of the Learning Curve on Visual and Refractive Outcomes of Small- Incision Lenticule Extraction. Cornea. 2017 Sep;36(9):.
27. Chan TCY, Lam SC, Mohamed S, Wong RLM. Survival analysis of visual improvement after cataract surgery in advanced retinitis pigmentosa. Eye (Lond). 2017 Dec;31(12):.
28. Li L, Cheng GPM, Ng ALK, Chan TCY, Jhanji V, Wang Y. Influence of Refractive Status on the Higher-Order Aberration Pattern After Small Incision Lenticule Extraction Surgery. Cornea. 2017 Aug;36(8):967-972.
29. Wong KH, Kam KW, Chen LJ, Young AL. Corneal blindness and current major treatment concern-graft scarcity. Int J Ophthalmol. 2017 Jul 18;10(7):.
30. Wang YM, Chan TCY, Yu M, Jhanji V. Shift in progression rate of keratoconus before and after epithelium-off accelerated corneal collagen crosslinking. J Cataract Refract Surg. 2017 Jul;43(7):929-936.
31. Zheng KK, Cai J, Rong SS, Peng K, Xia H, Jin C, Lu X, Liu X, Chen H, Jhanji V. Longitudinal Evaluation of Wound Healing after Penetrating Corneal Injury: Anterior Segment Optical Coherence Tomography Study. Curr Eye Res. 2017 Jul;42(7):982-986.
32. Ng ALK, Choy BNK, Chan TCY, Wong IYH, Lai JSM, Mok MY. Comparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome. Cornea. 2017 Jul;36(7):805-809.
33. Wu Z, Wang Y, Zhang J, Chan TC, Ng AL, Cheng GP, Jhanji V. Comparison of corneal biomechanics after microincision lenticule extraction and small incision lenticule extraction. Br J Ophthalmol. 2017 May;101(5):650-654.
34. Pahuja NK, Shetty R, Deshmukh R, Sharma A, Nuijts RMMA, Jhanji V, Sethu S, Ghosh A. In vivo confocal microscopy and tear cytokine analysis in post-LASIK ectasia. Br J Ophthalmol. 2017 Dec;101(12):.
35. Chan TC, Chow VW, Jhanji V. Collagen Cross-linking With Photoactivated Riboflavin (PACK-CXL) for Bacterial Keratitis After Small Incision Lenticule Extraction (SMILE). J Refract Surg. 2017 Apr 1;33(4):278-280.
36. Szeto SK, Chan TC, Wong RL, Ng AL, Li EY, Jhanji V. Prevalence of Ocular Manifestations and Visual Outcomes in Patients With Herpes Zoster Ophthalmicus. Cornea. 2017 Mar;36(3):338-342.
37. Zhao Z, Li J, Zheng Q, Lin W, Jhanji V, Chen W. Wet-Peeling Technique of Deep Anterior Lamellar Keratoplasty With Hypotonic Water and Blunt Dissection for Healed Hydrops. Cornea. 2017 Mar;36(3):386-389.
38. Kwok PW, Kam KW, Jhanji V, Young AL. Painless Acanthamoeba Keratitis with Normal Vision.
    Optom Vis Sci. 2017 Mar;94(3):432-435.
39. Li Z, Wang Y, Xu Y, Jhanji V, Zhang C, Mu G. The Evaluation of Corneal Fragility After UVA/Riboflavin Crosslinking. Eye Contact Lens. 2017 Mar;43(2):100-102.
40. Chan TC, Kwok PS, Jhanji V, Woo VC, Ng AL. Presbyopic Correction Using Monocular Bi-aspheric Ablation Profile (PresbyMAX) in Hyperopic Eyes: 1-Year Outcomes. J Refract Surg. 2017 Jan 1;33(1):37-43.
41. Ng AL, Kwok PS, Wu RT, Jhanji V, Woo VC, Chan TC. Comparison of the Demarcation Line on ASOCT After Simultaneous LASIK and Different Protocols of Accelerated Collagen Crosslinking: A Bilateral Eye Randomized Study. Cornea. 2017 Jan;36(1):74-77.
42. Chan TCY, Wan KH, Kang DSY, Tso THK, Cheng GPM, Wang Y. Effect of corneal curvature on optical zone decentration and its impact on astigmatism and higher-order aberrations in SMILE and LASIK. Graefes Arch Clin Exp Ophthalmol. Graefes Arch Clin Exp Ophthalmol. 2019 Jan;257(1):233-240.
43. Young AL, Kam KW. Pterygium: Surgical Techniques and Choices. Asia Pac J Ophthalmol (Phila). 2019 Nov-Dec;8(6):422-423.
44. Kam KW, Young AL. Fifteen-year results of a randomized controlled trial comparing 0.02% mitomycin C, limbal conjunctival autograft, and combined mitomycin C with limbal conjunctival autograft in recurrent pterygium surgery. Graefes Arch Clin Exp Ophthalmol. 2019 Oct 24.
45. Siu GDJ, Kam KW, Young AL. Amniotic Membrane Transplant for Bullous Keratopathy: Confocal Microscopy & Anterior Segment Optical Coherence Tomography. Semin Ophthalmol. 2019 May 27:1-5.
46. Kam KW, Wong PPY, Young AL.Tyrosine kinase inhibitor-induced corneal ulcers. Lancet Oncol. 2019 Jan;20(1):e65.

Program Faculty

• Prof Alvin L YOUNG, Director
• Dr Vanissa WS CHOW, Faculty
• Prof Ben NM LAM, Faculty
• Prof Vishal JHANJI, Faculty
• Dr Aziz KW KAM, Faculty