Program Overview

Dottorato in SPERIMENTAZIONE PRE - CLINICA E APPLICAZIONI INNOVATIVE DIAGNOSTICHE - TERAPEUTICHE NELLE SCIENZE BIOMEDICHE E CHIRURGICHE

Presentazione

The objective of this Doctoral Program is to train researchers with in-depth interdisciplinary skills in pre-clinical experimentation and innovative diagnostic and therapeutic applications in various biomedical and surgical disciplines, with particular attention to targeted therapies on molecular therapeutic targets.

The profile of these translational researchers (students from Biology, Biotechnology, and Medicine) fills the gap between basic research activities and application in clinical practice, utilizing the new Sapienza-Sant'Andrea facility, its dedicated research laboratories, and the proximity to Sapienza's didactic and assistance structures and the Sant'Andrea University Hospital.

Ph.D. students will be able to interpret and analyze individual and population data through data collection and big data analysis processes, aiming to obtain predictive (according to models) and trend analyses (instructive) to discover hidden patterns and connections between diagnostic, prognostic, and clinical response data to treatments.

In the various course activities, Ph.D. students will be engaged in:

• Studying biological models, both physiological and pathological aspects
• Using modern biomedical technologies to set up a correct and complete experimental path
• Applying translational research through the transfer of new biological knowledge into innovative diagnostic and therapeutic clinical and surgical pathways, with particular attention to evaluating new molecules, including those of natural origin, capable of modulating cellular metabolism for therapeutic purposes

During their training, Ph.D. students can:

1. Learn and use cutting-edge technologies: Next Generation Sequencing (NGS), proteomics, metabolic analysis
2. Collaborate with qualified clinical and surgical groups already involved in national and international research projects in various areas
3. Participate in courses and seminars of biological, biotechnological, bioinformatic, clinical interest to deepen the contents of the doctoral curriculum
4. Undertake internships in qualified Research Centers in Italy or abroad

The training program of the Doctoral Course includes the completion of teaching and research activities for 40 training credits (CFU) per year, for a total of 120 CFU/3 years, of which about 1/3 for teaching activities and about 2/3 for laboratory and pre-clinical and clinical research activities.

The research activity for the acquisition of CFU will be carried out with the help of a supervisor, who will have the task of articulating a research project with the Ph.D. student and verifying that the student fulfills the training tasks. From the second year of the course, part of the research activities can be carried out at international research institutes, based on shared programs with the hosting structure and approved by the College of Teachers of the Doctorate.

Finanziamenti

Ph.D. students can carry out their research projects within the framework of projects financed by the University or other public or private entities, national or international, obtained by the members of the College of Teachers. Some of these are listed below:

1. Cofinancing of the MIUR for programs of relevant national interest (COFIN-PRIN) titled "Cognitive dysfunction in dysmetabolic obesity and diabetes: role of inter-organ crosstalk and cellular ageing" (2020N5WK98_005) (Prof. Sesti G., Scientific Responsible of an operational unit)
2. Cofinancing of the MIUR for programs of relevant national interest (cofin-prin) titled "Effects of glucagon on hepatic expression of inflammatory markers" (2022F2NMAL) (Prof. Sesti G., Scientific Responsible of an operational unit)
3. BRIC ID project titled "Synergistic effects of oto
   eurotoxic agents, of known or to be determined toxicity, in inducing damage to the auditory system: development of exposure/effect biomarkers to be associated with audiologic variables in samples of exposed workers and patients affected by neurodegenerative diseases" (Head of the Department of BA) (Prof. Sciubba F.)
4. BRIC ID project titled "Evaluation of cumulative and integrated exposure to active substances of Plant Protection Products, for workers and residents in areas with high treatment intensity, with innovative methodologies for the search for indicators of dose and effect in biological and plant matrices" (Head of the Department of BA) (Prof. Sciubba F.)
5. BRIC ID project titled "Identification of biomarkers of exposure and effect from pollen allergens through combined evaluation of allergic reactivity, cytokine mediators, metabolites for the purpose of managing the risk of exposure to airborne allergens" (Head of the Department of BA) (Prof. Sciubba F.)
6. SEED PNR project titled "Improvement of the content of bioactive molecules in vegetable food matrices, in particular in red beet, following biostimulation" (Prof. Sciubba F.)
7. MISE project, Protocol no. 33940 - 09/02/2024 - AOO_IAI - AOO_Incentives Fund for Sustainable Growth - Innovation Agreements under the DM 31 December 2021 and DD 18 March 2022, F//01-04/X56 – Prevention and management of Dry Eye Syndrome characterized by chronicity and multifactoriality through bioactive molecules of natural origin properly vehicled (SOSTA) – Prof. Peluso and Prof. Calarco)
8. Project of Relevant National Interest (PRIN) - 2022 PNRR, Prot. P2022RZ8WM – Injectable Hydrogels for treatment of periodontal disease (HYPE); (Prof. Peluso and Prof. Calarco)
9. Project of Relevant National Interest (PRIN) - Bando 2022, Prot. 2022MN7M2M - Multilineage differentiating stress enduring (Muse) stem cells as a useful cell-based disease model for patients with IQSEC2 neural disorder- Prof. Peluso
10. POR FESR MISE Prog. n.F//01-02/X45 - Micro-nanodevices vehicling polyphenols isolated from olive oil waste as new food supplements (Micro-Poli); - Prof. Peluso
11. MISE project, Protocol no. 33940 - 09/02/2024 - AOO_IAI - AOO_Incentives Fund for Sustainable Growth - Innovation Agreements under the DM 31 December 2021 and DD 18 March 2022 - Sarcopenic syndrome with multimorbidity: prevention and management of chronic disease with bioactive molecules of natural origin with synergistic action (SYSTEM).- Prof. Peluso
12. Sapienza University of Rome - Research Projects (Small, Medium) - Medium Projects Immune humoral and cell-mediated immunity in carotid and coronary arteriosclerosis. Responsible: TAURINO Maurizio
13. Sapienza University of Rome - Research Projects (Small, Medium) - Medium Projects ALTAIR PROTOCOL: ALTo endogrAft Italian Registry Responsible: TAURINO Maurizio
14. Neurotensin at the crossroad between impaired gut homeostasis and metabolic disease in humans. Prot. n. RME92223. Research Projects Ateneo Sapienza 2022. Component Prof. Zampieri M.
15. Impact of oxidative stress on the regulatory interplay between PARylation and DNA methylation profile in type2 diabetes mellitus. Prot. n. RM12117A8614B6F9. Research Projects Ateneo Sapienza 2021. Responsible Prof. Zampieri M.
16. Increased PARylation impacts DNA demethylation processes in type 2 diabetes mellitus. Prot. n. RMAC70973A. Research Projects Ateneo Sapienza 2020. Responsible Prof. Zampieri M.
17. Sapienza University of Rome - Research Projects (Small, Medium) - Medium Projects 2020 (Responsible Prof.ssa Maria Rosaria Ricciardi) prot RMB6DF0CBB, “Integrating profiling technologies to identify biomarkers for therapeutic sensitivity and resistance at transcriptomic, proteomic and metabolic levels in Multiple Myeloma cells”.
18. Sapienza University of Rome - Research Projects (Small, Medium) - Medium Projects 2021 (Responsible Prof A.Tafuri) prot RM12117A813AB88A, “ACUTE MYELOID LEUKEMIA WITH COMPLEX KARYOTYPE: DISSECTION OF THE METABOLIC PROFILE FOR THERAPEUTIC INTERVENTION.”
19. Sapienza University of Rome - Medium Scientific Equipment 2023 - Medium Equipment 3 (Responsible Prof. A. Tafuri) - MAB47234 Cell metabolism profiling through Seahorse technology: a common key to understand mechanisms of dysregulation and to develop molecular targeted therapies.

Collaborazioni

The various members of the College of Teachers have numerous collaboration activities with national and international institutions.

In addition, five teachers belong to several well-known international research institutions (MD Anderson, Houston, MSKCC of New York).

Collaborazioni Internazionali in Evidenza

1. Leukemia Department, MD Anderson Cancer Center, Houston TX, USA (Prof. A. Tafuri, Prof.ssa Ricciardi)
2. Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey (Prof. Peluso)
3. Laboratory of Biotechnology, Environment, Agrifood, and Health (LBEAS), University of Sidi Mohamed Ben Abdellah, Faculty of Sciences, University Sidi Mohammed Ben Abdellah, BP 1796-ATLAS Fes, Morocco (Prof. Calarco)
4. Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, United States (Prof. Calarco)
5. Fluid Dynamics of Complex Biosystems, School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany (Prof. Calarco)

Collaborazioni con Istituzioni Italiane

1. Department of Clinical Medicine and Molecular Medicine of the University of Rome "Sapienza" and the Department of Medical and Surgical Sciences of the University of Magna Græcia of Catanzaro, aimed at carrying out a common Research Project titled "Effect of bempedoic acid on hepatic glucose" (Prof. Sesti).
2. INAIL, aimed at carrying out BRIC projects issued by this entity (Prof. Sciubba)
3. Department of Restorative Dentistry, University of Naples Federico II, via S. Pansini 5, 80131 Napoli, Italy (Prof. Peluso)
4. Division of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
5. Department of Chemical, Materials and Production Engineering (DICMaPI) - University of Naples Federico II, Napoli, Italy (Prof. Calarco)
6. IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna
7. IRCCS INRCA, Ancona
8. CREA-Centro di Ricerca Zootecnia e Acquacoltura, Monterotondo (RM)
9. Istituto di Biologia e Patologia Molecolari, CNR, Roma

The activities presented on this page are financed totally or in part by the funds of the National Recovery and Resilience Plan. The list and purposes of the activities undertaken by Sapienza are described on the Sapienza for the Pnrr page.