Program Overview

Introduction to the Integrated Research Training Group

The integrated research training group 'Structural Dynamics of GPCR Activation and Signaling' is part of Collaborative Research Centre 1423, which focuses on how cells communicate via important receptors. The spokesperson of the research training group is Professor Daniel Huster.

Program Overview

Cells communicate with each other and their environment via receptors. These are located in the cell wall and recognise a specific signal, which they transmit inside the cell and thus cause the cell to react. G protein-coupled receptors (GPCRs) are the largest group of these membrane receptors and found in almost all living organisms. GPCRs have a pivotal role in medicine: Approximately 30 per cent of all prescription drugs act via these receptors, but so far the potential of only a small group of receptors has been exploited.

Program Focus and Structure

The research training group has a special focus on the career development of its doctoral researchers. The doctoral programme includes:

• Scientific modules
• Laboratory rotations at Vanderbilt University in the United States
• An annual summer school
• Courses on professional skills such as:
  • Leadership
  • Communication
  • Research data management

Research Areas

The program focuses on the structural dynamics of GPCR activation and signaling, which is a crucial aspect of cell communication. Understanding how GPCRs function and how they can be targeted for therapeutic purposes is a key area of research within the program.